WNT Stimulation Dissociates a Frizzled 4 Inactive-State Complex with Gα12/13

The Wnt receptor Frizzled-4 modulates ADAM13 metalloprotease activity.

Cranial neural crest (CNC) cells are a transient population of stem cells that originate at the border of the neural plate and the epidermis, and migrate ventrally to contribute to most of the facial structures including bones, cartilage, muscles and ganglia. ADAM13 is a cell surface metalloprotease that is essential for CNC cell migration. Here, we show in Xenopus laevis embryos that the Wnt r...

Wnt - Frizzled Signaling via Cyclic

1. Abstract 2. Atypical, non-canonical pathways of Wnt-Frizzled signaling 3. Frizzled-2 as a G-protein-coupled receptor 4 Discovery of Gt alpha (transducin) expression in embryonic cells 5. Inhibition of Frizzled-2 signaling by inhibitors of cyclic GMP phosphodiesterase 6. Frizzled-2 regulates intracellular concentration of cyclic GMP 7. Inhibition of cyclic GMP phosphodiesterases blocks develo...

P-17: Modulation of Wnt/?catenin and AktSignaling Activities in Rat Granulosa Cells byUsing Recombinant Secreted Frizzled RelatedProtein Type-4

Wnt/Frizzled signaling in hepatocellular carcinoma.

The Wnt/Frizzled (FZD) signaling cascade is important for cell fate determination during embryonic development as well as maintaining tissue homeostasis in the adult. In addition to these physiologic roles, studies have shown that deregulation of Wnt/FZD signaling occurs during carcinogenesis. As an example, over 90% of the colorectal cancers have mutations in adenomatous polyposis coli (APC) o...

Structural basis of Wnt recognition by Frizzled.

Wnts are lipid-modified morphogens that play critical roles in development principally through engagement of Frizzled receptors. The 3.25 angstrom structure of Xenopus Wnt8 (XWnt8) in complex with mouse Frizzled-8 (Fz8) cysteine-rich domain (CRD) reveals an unusual two-domain Wnt structure, not obviously related to known protein folds, resembling a "hand" with "thumb" and "index" fingers extend...